Apelin Receptor (APJ) Expression during Cardiopulmonary Bypass in Children Undergoing Surgical Repair

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Apelin Receptor (APJ) Expression during Cardiopulmonary Bypass in Children Undergoing Surgical Repair

BACKGROUND AND AIMS In human adults, and animals, the Apelin-APJ ligand-receptor system is emerging as having a role in the pathogenesis of cardiovascular function and heart failure. The aim was to investigate expression, and regulation by oxygen, of the Apelin APJ receptor (APJ) in myocardium obtained from children undergoing corrective surgery with cardiopulmonary bypass for repair of congeni...

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The Expression of Apelin and Its Receptor Apj during Different Physiological Stages in the Bovine Ovary

Recent studies implicate that apelin and its receptor APJ may have important role for the modulation of angiogenesis. The aim of this study was to further characterise the regulation of apelin/APJ system in bovine ovary. Experiment 1: corpora lutea (CL) were assigned to the following stages: days 1-2, 3-4, 5-7, 8-12, 13-16, >18 (after regression) of oestrous cycle and of gravidity (month <3, 3-...

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Cerebral oxygenation during cardiopulmonary bypass in children.

OBJECTIVE Previous work has found cerebral oxygen extraction to decrease during hypothermic cardiopulmonary bypass in children. To elucidate cardiopulmonary bypass factors controlling cerebral oxygen extraction, we examined the effect of perfusate temperature, pump flow rate, and hematocrit value on cerebral hemoglobin-oxygen saturation as measured by near infrared spectroscopy. METHODS Forty...

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Zinc in children undergoing cardiac surgery with cardiopulmonary bypass.

During cardiac surgery with extracorporeal circulation (ECC), a series of immunological and inflammatory alterations occur, which trigger oxidative stress1,2. Under the nonphysiological conditions during the ECC and due to the alterations related to ischemia-reperfusion, a large amount of free radicals is formed3. These are responsible for systemic inflammation and considerable structural and f...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2014

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0106262